NEW RGD targeted delivery systems as anticancer treatment strategy

NEW RGD targeted delivery systems as anticancer treatment strategy
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Below are the main points the writer should consider for creating the whole of the review based thesis including abstract, materials/methods, discussion, conclusion and references (many references at the end, 30-50 references at least) , and I need the sources of materials used at the end.

The main subject is : “RGD based targeted drug delivery systems in cancer Chemotherapy and cancer treatment”.
The following points must be referred and expanded while writing the thesis:
What is integrin and what are its subtypes? To what receptors it is related to and upond its activation what happens?
Where integrins are found?
functions of integrins?
To what ligands integrin binds?
Intracellular functions of Integrins?
Integrins and other RGD based receptors, what happens to them in case of cancer or metastasis, or related diseases?
How Integrin mediated signalling pathway works?
RGD applications in tumor therapy and chemotherapeutics?
Structure, activation and interactions related to integrins?
Overall, how RGD or its related mechanisms can be used in the treatment of cancer? What may be its potential uses in Pharmacy or medicine in the future?

____________________________

I will not need a data analysis or data collection. But when you finish with writing up, please be sure to provide followings:
Revisions within 30 days
Copy of the cited sources

Please find attached some articles and resources (do not use wikipedia, I attached it for the purpose of providing additional information). Feel free to use them all, but you obviously need to find even more articles or resources for the thesis.

I hope this helps. Should you have additional queries please do not hesitate to contact me straight away. I were not able to send these files on the system, which is the reason I am sending them via this email.

This is like the continuation of your previously written RGD paper.

-The write up must be in masters level and should consist of 8 pages.

– I need 15-20 references.

-Please stick to the following guidelines and focus your work on covering all the points in detail:

1. How RGD-drug link as anticancer therapy works, what are the mechanisms involved?

2. There are certain hypothesized advantages for RGD linked drugs such as:

• Increased uptake of drug
• Increased efficacy of drug
• Lower side effect

– Were these results as expected according to the studies (consider both review articles and research articles in field)
– What other potential advantages would exist? Why RGD linked drug delivery would be beneficial?

3. What type of linker(s) are required to connect RGD with drug? PEG is one of them, what about others? And how these linkers can be linked to RGD? (synthetically, adding functional groups etc.?) What type of conjugation technique can be used for such linkage?

4. Compare various types of RGD systems. Discuss advantages and disadvantages of each. Search for review papers for these.

5. RGD-linked drug uses:

– RGD-drug
– RGD-polypeptide/protein
– RGD-drug delivery system
– RGD-diagnosis imaging
How RGD can be used for the purposes listed above? Discuss in detail.
6. What type of drug molecules can be RGD linked drug molecules? (Small molecule drugs? Certain anticancer drugs having special structures? Why?) Discuss and comment.

7. How RGD-linked drugs, when administered to humans, will likely interact or affect cells, or tissues? With what mechanisms and why would these be beneficial or promising for cancer treatments? What would be the difference from already existing cancer medications or treatments available?
The following points must be referred and expanded while writing the thesis:

What is integrin and what are its subtypes? To what receptors it is related to and upond its activation what happens?

Where integrins are found?

functions of integrins?

To what ligands integrin binds?

Intracellular functions of Integrins?

Integrins and other RGD based receptors, what happens to them in case of cancer or metastasis, or related diseases?

How Integrin mediated signalling pathway works?

RGD applications in tumor therapy and chemotherapeutics?

Structure, activation and interactions related to integrins?

Overall, how RGD or its related mechanisms can be used in the treatment of cancer? What may be its potential uses in Pharmacy or medicine in the future?

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